Transduction of Isoniazid Susceptibility-Resistance and Streptomycin Resistance in Mycobacteria
نویسندگان
چکیده
منابع مشابه
Transduction of isoniazid susceptibility-resistance and streptomycin resistance in mycobacteria.
Transduction of resistance to isoniazid and streptomycin as well as susceptibility to isoniazid in Mycobacterium smegmatis SN2 has been demonstrated. A method has been described for the selection of isoniazid-susceptible variants after transduction of susceptibility.
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The rapid rate at which bacteria develop resistance to streptomycin has been demonstrated in vitro and in vivo. Quantitative studies have been made of certain species of non-acid-fast organisms which give rise to streptomycin-resistant variants (Klein, 1947; Alexander and Leidy, 1947; Klein and Kimmelman, 1946). These investigations show that small numbers of resistant cells are present in susc...
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Cell-free extracts of Streptomyces bikiniensis contain an adenosine 5'-triphosphate-dependent kinase which inactivates streptomycin (Sm) and dihydrostreptomycin by phosphorylation. The products have been identified as streptomycin 6-phosphate and dihydrostreptomycin 6-phosphate. Activity was not present in logarithmic-phase cells, which were susceptible to 25 mug of Sm per ml. In stationary-pha...
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We developed a simplified microarray test for detecting and identifying mutations in rpoB, katG, inhA, embB, and rpsL and compared the analytical performance of the test to that of phenotypic drug susceptibility testing (DST). The analytical sensitivity was estimated to be at least 110 genome copies per amplification reaction. The microarray test correctly detected 95.2% of mutations for which ...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1973
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.4.6.643